1. 1980-Wada et al, Infection and Immunity, 29 pp 545-550 "Neutralizing Activity Against Clostridium Difficile Toxins in the Supermatants of Cultured Colostral Cells." Colostrum immune factors neutralize crude toxins.

2. 1983-Staroscic et al., writing for Molecular Immunology state "a small-chain, polyprotein-rich peptide in colostrum has the same ability to regulate the activity of the immune system as the hormones of the thymus gland. It activates an underactive immune system, helping move it into action against disease-causing organisms. It also suppresses an overactive immune system, often in autoimmune diseases." In another review, S. Hopkins and N. Rothwell, writing in Trends in Neuroscience, suggest links to inflammation, nervous disorders, and even sleep patterns".

3. 1988-Julius, Janusz, Lisowski, Journal of Immunology, Vol. 140, pl1366-71 Dept. of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada: A colostral protein (PRP) that induces the growth and differentiation of resting B lymphocytes. "PRP (Protein-rich Polypeptide) is the first protein of mammalian origin that induces the growth and differentiation of reacting B lymphocytes. PRP has been isolated from sheep and cow's colostrum and is not species specific. Splenocytes from neonatal mice responded robustly to PRP with the growth and differentiation of contained B cells to plaque formation. PRP did not induce detectable lg isotype switching".

4. 1989-Tokuyama and Tokuyama, Dept. of Molecular Immunology, Cancer Research Institute and Dept. of Nuclear Medicine, Kananawa, Japan Harwood Academic Publishers, UK. Cellular Biology Report 13, P P P 251-258; "Bovine Colostric Transforming Growth Factor-B-Like peptide induces growth inhibition and changes morphology of human osteogenic sarcoma (cancer) cells." TgF B produced cell destruction in certain human cancer (sarcoma) cells in cell culture growth experiments in Japan.

5. 1990-Tokuyama, et al., Dept. of Molecular immunology, Cancer Research Institute and Dept. of Nuclear Medicine, Kananawa, Japan Harwood Academic Publishers, UK. Reported two new Proteins discovered in Bovine Colostrum: BC-1 and BC-2 belong to a new class of mitogen inhibitors. Reported that through biological activities resemble TGF-B. Showed inhibitory effect on some sarcoma (cancer) tumor cell lines in sutro.

6. 1991-Bocci, Bremen, Corradeschi, Luzzi and Paulesu, Journal Biology Regul. Homeost. Agents Oct-Dec. 5 (4): 141-4 Reported:

1. Immunoglobulins can not be received through the placenta.
2. Colostrum has a well acknowledged crucial value for the survival of animal species.
3. Presence of 4 Cytokines verified in bovine colostrum: Interlukin 1&6, tumor necrosis factor and interferon gamma.
4. Exert an important immunostimulatory role particularly on the oropharyngeal-associated lymphoid tissue.
5. Administration can provide benefits in aged or immunodeficient people.
6. Nature has used the oral route for the development of the immune system since the origin of mammals (safe and effective).
7. Oral administration of immunofactors is very simple, inexpensive, free of side effects and may be vastly beneficial in veterinary and human medicine to correct immunodeficiency.

7. 1993-Tokuyama and Tokuyama, Journal of Dairy Research, Vol. 60: 99-109 (Printed in Great Britain) Dept. of Nuclear Medicine, Fasc. Med. Dept. Mol. Mol. Imm. Cancer Research Institute. Kanazawa University, Japan reported:

1. Bovine Colostrum contains TGF-B.
2. Exerts positive regulatory effects on accumulation of extracellular matrix proteins.
3. Suppressive effect on cytoxic monocytes.
4. Potent inhibiting effect on dependent growth of human osteosarcoma (cancer) cells (76% inhibition).
5. Mediator of fibrosis and angiogenisis (Roberts et al., 1986), wound healing (Sporn et al., 1983) and bone formation (Centrella et al., 1987)

8. 1994-Chaumell, Liolet, Kogbe, Adv. Exp. Med. Biol. Report of clinical study Vol. 350 pp 595-99 Reported effective treatment of eye infections with bovine colostrum lactoserum i.e.: reduction of glaucoma, scaring after injury or surgery, reduction in eye lesions. Also reported: Science News vol. 133 p 195 Breast Milk stimulates immunity: "Researchers reporting evidence that colostrum stimulates babies own immune systems. Speeds maturation of B. Lymphocytes (a type of white blood cell) and primes them for production of antibodies, according to M. Julius of McGill University, Montreal. March 1 Journal of immunology reported sheep's colostrum enhances growth and differentiation of cultured white blood cells. Similar activity in cow's and human colostrum. Substance an also activate macrophages".

9. 1995-Bhora, et al., Jour. Surg.Res. Vol. 59 p 236-44: Effect of growth factors on cell proliferation in human skin: "the failure of chronic wounds to heal is a major medical problem. Studies suggest an important role for growth factors in promoting would healing. Conclusion: Fibroblast growth factor IGF-1 and epithelial growth factor are important for wound healing". Treatment implications for trauma and surgical wounds, accelerated healing possible.

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